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ea0035oc2.4 | Adrenal clinical | ECE2014

Detection of pheochromocytoma by enzyme immunoassay measurements of plasma metanephrines requires appropriately established upper cut-offs of reference intervals

Weismann Dirk , Raida Anna , Deutschbein Timo , Prejbisz Aleksander , Januszewicz Andrzej , Willenberg Holger S. , Peitzsch Mirko , Darr Roland , Klemm Reiner , Manz Georg , Bidlingmaier Martin , Eisenhofer Graeme , Fassnacht Martin

Aim: To determine diagnostic performance of normetanephrine (NMN) and metanephrine (MN) measured by an enzyme immunoassay (EIA) compared with liquid chromatographictandem mass spectrometry (LC-MS/MS).Methods: Subjects included 341 patients (174 males) with a mean age of 52 year (range 1386) tested for PHEO, which was confirmed in 54 patients. Samples where collected from fasting patients after 30 min of supine rest and analyzed for NMN, MN an...

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Detection of pheochromocytoma by enzyme immunoassay measurements of plasma metanephrines requires appropriately established upper cut-offs of reference intervals

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